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Description
Medications like orforglipron (an oral, non-peptide GLP-1 agonist), survodutide (a dual glucagon/GLP-1 agonist), and CagriSema (combining cagrilintide with semaglutide) are advancing through clinical trials

Peer review Peer review information Nature Communications thanks Luca Chiovato and the other, anonymous, reviewer(s) for their contribution to the peer review of this work
However, Zepbound's gastrointestinal effectsincluding constipation in 16-17% and diarrhea in 18-24% of patientsmay indirectly increase hemorrhoid risk through straining or anal irritation
Settlement arising from death of a pedestrian caused by distracted driver of a box truck

Physician uncertainty and diagnostic discomfort may confirm patient perceptions of being misunderstood
