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Medications like orforglipron (an oral, non-peptide GLP-1 agonist), survodutide (a dual glucagon/GLP-1 agonist), and CagriSema (combining cagrilintide with semaglutide) are advancing through clinical trials

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Peer review Peer review information Nature Communications thanks Luca Chiovato and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

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However, Zepbound's gastrointestinal effectsincluding constipation in 16-17% and diarrhea in 18-24% of patientsmay indirectly increase hemorrhoid risk through straining or anal irritation

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Settlement arising from death of a pedestrian caused by distracted driver of a box truck

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Physician uncertainty and diagnostic discomfort may confirm patient perceptions of being misunderstood

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