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In clinical practice, dermatologists can begin by identifying HS patients with concurrent metabolic comorbidities who may benefit most from GLP-1 therapy

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Older drugs including orlistat, liraglutide and metformin do not, on this evidence, clear the bar for a meaningful reductions in weight over lifestyle change alone

Allosteric modulation of the activity of the glucagon-like peptide-1 (GLP-1) metabolite GLP-1 9-36 amide at GLP-1 receptor

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