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Statistical analysis Statistical tests are indicated in figure legends with sample sizes

- Increased -cell proliferation - Enhanced cell survival with reduced apoptosis - Restoration of islet mass in preclinical metabolic models - Improved glucose stimulated insulin secretion This synergy has ensured success in regenerative therapies for type 1 and type 2 diabetes

thus, initial interest focused on glucagon antagonism as antihyperglycaemic therapy [68]