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At the end of treatment, mice were subject to tissue collection under anesthesia with intraperitoneal injection of pentobarbital (35 mg/kg)

By breaking down a signaling molecule that keeps smooth muscle relaxed, PDE5 helps the arteries constrict and allows venous drainage to resume

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Cyanidin-3-O-glucoside increases GLP-1 levels in diabetic mice and may promote GLP-1 secretion by regulating intestinal flora metabolism, particularly key metabolites like short-chain fatty acids, thus supporting intestinal and glucose homeostasis

(2) Building on this, Kanda and colleagues explored the physiologic effects of the GLP-1 RA liraglutide on Ishikawa endometrial cancer cells using tissue samples to determine the pathologic function on GLP-1 receptors in individuals with endometrial cancer in the second study