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An important nuance from the NEJM paper: The paper notes that the mechanism "may further amplify heart rate elevation" through the glucagon receptor, while acknowledging this is consistent with the known pharmacology rather than proven in direct mechanistic studies specific to retatrutide

To be clear, we do not know , but the math doesnt add up

In addition, NPY2R (Nguyen et al., 2011) is expressed mainly in the human ileum, colon, pancreatic gland, and prostate regions, whereas NPY4R (Lin et al., 2009) and NPY5R (Reichmann et al., 2016) are mainly expressed in brain tissue

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Wallings, R