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This Comment highlights emerging evidence and advocates for clinical strategies that prioritize muscle preservation to ensure the long-term success and safety of pharmacological weight management.

We also describe the development of incretin-based pharmacotherapy, starting with exendin- 4 and ending with the identification of multi-incretin hormone receptor agonists, which appear to be the next major step in the fight against T2DM and obesity

It highlights the PIONEER clinical trial programme results, and reviews the efficacy, safety and tolerability.

as the diagnosis of clinical obesity will be redefined, while evidence substantiating the value of AOMs begins to accumulate in the real world