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Particular caution is needed for patients with heart failure with reduced ejection fraction (HFrEF)

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Kidney dysfunction or recurrent volume depletion: severe vomiting or diarrhea can worsen renal function

Comparative Effectiveness Research: A meta-analysis by Ahmann, A.J., in Diabetes, Obesity and Metabolism, compared the efficacy and safety of semaglutide with other GLP-1 receptor agonists and SGLT2 inhibitors, offering valuable insights into its relative performance and patient selection criteria

[1] [3] If you suspect nocturnal hypoglycaemia, your healthcare team may recommend checking your blood glucose levels upon waking or occasionally during the night if symptoms persist