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14 There remains a compelling need for more effective obesity interventions that optimize health gains as well as weight reduction, particularly for populations with a high burden of complications and a reduced quality of life

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However, all drugs in development face the challenge of showing both analgesic and structural properties 61,62,63,64

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A follow-up trial in July 2024 (median follow-up = 3.4 years) confirmed these results, showing a 24% reduction in the primary outcome risk in the semaglutide group compared to the placebo group