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Significant weight reduction can lead to decreased skin elasticity, increased skin laxity, dryness, and subjective changes in skin texture

As your treatment progresses, your healthcare provider will closely monitor your response to the medication and gradually increase the dose every four weeks, based on your tolerance and weight loss progress

In PIONEER 6 trial, 3183 patients with T2DM were randomized to either oral semaglutide or placebo were observed for cardiovascular events up to a median of approximately 16 months

Some individuals report that side effects like nausea or reduced appetite are most pronounced in the first few days and improve as the week progresses

While these medications primarily reduce fat body mass (FBM), loss of lean body mass (LBM) can also occur, raising concerns about muscle loss in susceptible populations, such as frail individuals and older adults