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Differences were considered statistically significant when the confidence intervals did not overlap 1.0

Special Populations: Age, Pregnancy, and Genetic Predisposition GLP-1 medications are not recommended during pregnancy or breastfeeding due to limited safety data

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Consider: Baseline blood pressure and heart rate measurement before starting combination therapy Regular monitoring during dose titration of either medication Prompt evaluation of palpitations, chest pain, or shortness of breath Caution in patients with pre-existing cardiovascular disease , including coronary artery disease, arrhythmias, or uncontrolled hypertension ECG evaluation if indicated by clinical history or symptoms Nutritional adequacy must be maintained

what doubts they have," he said