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The approval was based on data from two randomized, double-blind, placebo-controlled studies involving more than 3,000 overweight or obese adults

Especially regarding the central nervous system, the expression of GLP-1 receptors in reward-related regions, such as the hypothalamus, amygdala, nucleus accumbens, paraventricular nucleus, ventral tegmental area, locus coeruleus, and brain stem [21] may suggest a possible association between reward learning and symptoms like anhedonia in diseases such as depression

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Abbreviations ASC: Apoptosis speck-like protein -SMA: -smooth muscle actin BLM: Bleomycin ECM: Excessive extracellular matrix F-6-P: Fructose-6-phosphate F-1, 6-BP: Fructose-1, 6-bisphosphate F-2, 6-BP: Fructose-2, 6-bisphosphate Fn: Fibronectin GLP-1R: Glucagon-like peptide-1 receptor GSDMD: Gasdermin D IPF: Idiopathic pulmonary fibrosis IL-18: Interleukin 18 IL-1: Interleukin 1 NLRP3: Nucleotide-binding and oligomerization domain, leucine-rich repeat, and pyrin domain-containing 3 Pan-Kla: Pan-histone lysine lactylation PFK1: 6-phosphofructo-1-kinase PFKFB3: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 TNF-: Tumor necrosis factor TGF-1: Transforming growth factor 1 References Perrot CY, Karampitsakos T, Herazo-Maya JD

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