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Description
The results of recent work reveal that GLP-1R is expressed in neuropeptide Y (NPY)-positive neurons in the AP and that GLP-1 can directly or indirectly inhibit neuronal signaling in the anorexigenic NPY system via agonism of GLP-1R 19
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What raises concerns are some of the recent reports of serious ADRs associated with GLP-1RAs: (i) Pfizers disclosure of elevated aminotransferases in users of lotiglipron (a novel oral GLP-1RA) is indicative of hepatocellular injury [11]
Discussion PCOS is a prevalent, highly heterogeneous condition affecting women of reproductive age, frequently involving metabolic comorbidities
