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Funding This work was supported by the National Natural Science Foundation of China (81974254, 31870906, and 82170470)

Studies show that stopping these medications often results in partial or full weight regain because appetite and metabolic rates return to baseline

This limitation is especially important in PCOS, where improved natural conception may plausibly reflect restoration of ovulatory opportunity after weight loss rather than a direct fertility-enhancing effect of the drug itself

Detailed Category Analysis# Mechanism of Action# Bioglutide : First-in-class oral quadruple receptor agonist targeting GLP-1, GIP, glucagon, and IGF-1 receptors simultaneously

Oral semaglutide must be taken on an empty stomach