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Description
Patients receiving semaglutide (0.5 or 1.0 mg) for 104 weeks demonstrated a significantly higher risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or required procedural treatment compared to those receiving placebo (HR, 1.76

Curr Diabetes Rev 14(3):273279 Mousavi A et al (2025) Safety, efficacy, and cardiovascular benefits of combination therapy with SGLT-2 inhibitors and GLP-1 receptor agonists in patients with diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials

Let your provider know your goals and your budget

Muscle loss risk at significant caloric deficits, muscle loss becomes a real concern

Patients should monitor glucose levels closely during this transition period
