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In summary, bridging the gap between pharmacogenomic discovery and clinical application for tirzepatide demands (1) large-scale, multi-ethnic, prospective druggene interaction studies

We have an obligation to understand the full biology of these drugs, not just the intended effect

Semaglutide and liraglutide are GLP-1RAs, while tirzepatide is a dual GLP-1/gastric inhibitory polypeptide co-agonist

1 This article explores the emerging role of GLP-1RAs, originally developed for diabetes and obesity, in treating alcohol addiction

The practical impact is minimal
