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ligand binding makes the cleavage site accessible, leading to shedding of the Notch ectodomain as the first step of signal transduction [[3][3], [4][4]]

In addition to diabetes and obesity, GLP-1

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This review article discusses the potential antidepressant effects of GLP-1RAs, especially in the context of their action on the processes related to neuroprotection, inflammation, stress response, energy metabolism, gut-brain crosstalk and the stability of the gut microbiota