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Central nervous system GLP-1 receptors are distributed throughout brain regions implicated in depression, including the hippocampus, prefrontal cortex, and nucleus accumbens

The cardioprotective effects of mesenchymal stem cells, GLP-1RAs or pioglitazone may improve mitochondrial function via regulating autophagy and inflammatory signaling [87]

GIP supplementation was also shown to be ineffective in the 1990s when intravenous (IV) GIP was introduced to hyperglycemic patients with no effect on their blood glucose though physiologic rather than pharmacologic concentrations were supplied [20]

Isolation of the peptide

However, this is harder to self-administer correctly, so we usually recommend sticking with the thigh or stomach