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GPCRs and their complexes have proven to be formidable targets for X-ray crystallography, often necessitating extensive engineering for conformational stabilization and crystallogenesis

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Dulaglutide 0.75 mg (n = 251) resulted in a mean increase in 24-h HR of 1.3 bpm, whereas a 3.5-bpm increase in HR was observed at the end of the study for the 1.5-mg dose (n = 254)