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Based on this review, evidence from head-to-head and insulin-comparator trials demonstrates that dual GIP/GLP-1 co-agonism consistently overcomes metabolic plateaus that result from single-pathway therapy, producing superior glycated hemoglobin reduction, bariatric-level weight loss (up to 25.3%), and robust macrovascular and heart failure protection, including a 38% reduction in composite cardiovascular risk among patients with heart failure with preserved ejection fraction (HFpEF)

Among patients who discontinued semaglutide after 6 months (n=25), mean weight increased from 74.611.3 to 83.212.3 kg by 12 months, with 32% regaining to baseline weight or higher

Semaglutide and Tirzepatide are both innovative drugs that have revolutionized diabetes and obesity management.