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Pooled data from these three trials showed that rates of HF hospitalization were not significantly different between DPP-4i and placebo, suggesting that the effect may not be a class effect [100, 101]

There was an observed U-shape association between serum DPP-4 and mortality in patients with chronic systolic HF, and Loureno et al

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In this regard it has been shown that apoptotic cell clearance induces the expression of various M2-activation-associated molecules in macrophages including IL-10, TGF and CD206 52