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The search terms used included GLP-1 agonists, Glucagon-Like Peptide-1 Receptor Agonists, semaglutide, Ozempic, Wegovy, liraglutide, bone health, orthopedic surgery, arthroplasty, post-operative complications, complications, bone health, bone strength, osteogenesis, and bone metabolism. To ensure the relevance and quality of the studies, we established specific inclusion and exclusion criteria

Hormonal Balance: Weight changes associated with Ozempic can affect various hormone levels, potentially influencing mood and anxiety [8]

This allows the medication to bypass the digestive system and enter the bloodstream directly

Multiple randomised, placebo-controlled trials have tested GLP-1 drugs as add-on therapy to insulin in people with T1D, and the picture that emerges is consistent, if modest: meaningful weight loss, real reductions in daily insulin needs, and improvements in CGM time in range

GLP-1 receptor agonists appear to shift immune activity from inflammatory to regulatory without compromising protective immunity