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Your provider adjusts your dose over time based on your tolerance, side effects, and weight loss progress
For example, research shows that after surgery, 1 out of 4 adults still required diabetes medication but none of the adolescents needed it
Finally, a May 2025 head-to-head trial published in NEJM compared tirzepatide with semaglutide directly
Some people also experience body aches , insomnia , or muscle pain on tirzepatide, though these are less common than the GI effects
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