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Blood work during this washout period should show a gradual return of glucose and lipid markers toward pre-treatment values

Some patients benefit from coaching, nutrition planning, movement support, body composition tracking, hormone evaluation, or maintenance planning without prescription weight-loss medications

Key takeaways Cleveland Clinic real-world data presented at ASCO 2026 found patients who started a GLP-1 receptor agonist (semaglutide or tirzepatide) after a breast cancer diagnosis were about 43% less likely to progress to Stage IV disease than patients who started a DPP-4 inhibitor (hazard ratio 0.57, 95% CI 0.46 to 0.71

Patients who completed adequate semaglutide titration, achieved partial but insufficient weight loss, and are looking for the next pharmacologic step benefit directly from tirzepatide's added GIP receptor mechanism

Keep fast-acting carbohydrates such as glucose tablets on hand