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According to the FDA prescribing information, these include nausea, vomiting, diarrhea, abdominal pain, and constipation

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CrossRef Flavonoids Derived from Opuntia ficus-indica Fruit Alleviate Renal Injury in Diabetic Nephropathy Mice by Altering Gut Microbiota and Promoting the Production of SCFAs Haiping Liao, Yunyi Zhao, Yongheng Liang, Kang Zou Nutrients.2025