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According to a case report published in the Journal of Investigative Medicine in October 2021, a 52-year-old female taking semaglutide reported experiencing severe gastric pain, accompanied by fullness, bloating, and vomiting within one month of starting weekly injections

The net effect of the mismatch between increased ATP demand and decreased ATP generation is increased renal oxygen consumption, ultimately rendering the kidney susceptible to renal hypoxia [15]

GLP- 1 receptor activation has longer-term consequences, such as increased b cell proliferation and neogenesis along with cytoprotective (non-insulinotropic) effects [4551]

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