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Global Burden of Obesity in 2005 and Projections to 2030

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In addition, a GLP-1R agonist was shown to act indirectly through gamma-Aminobutyric acid neurons to inhibit NPY/AgRP neurons in the ARC44)

Nauck MA, DAlessio DA, Tirzepatide (2022) A dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction
