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Pharmacokinetics (How Long They Last): Semaglutide: Half-life: Approximately 7 days Reaches steady state: After 4-5 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 1-3 days after injection Tirzepatide: Half-life: Approximately 5 days Reaches steady state: After 4 weeks Duration of action: Remains active for one week between doses Time to peak concentration: 8-72 hours after injection Both medications are designed for once-weekly dosing and maintain therapeutic levels throughout the week

Electrolytes We touched on electrolytes in the hydration section, but they deserve their own discussion in the supplement context

It mimics hormones released after eating, causing increased fullness, longer digestion, and lower blood sugar levels

Some users at these doses benefit from understanding the tapering process in case they decide the higher doses are not sustainable