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While the exact cause of PCOS is unknown, factors contributing to its onset include chronic inflammation, higher levels of androgens (male sex hormones that impede ovulation), weight gain, and insulin resistance, a precursor to prediabetes and Type 2 diabetes that impairs the bodys ability to use glucose efficiently

The effects of exogenous GLP-1 observed after administration to patients with type 2 diabetes (11) include: Decreased glucagon concentrations Improved insulin sensitivity Decreased A1C Slowed gastric emptying Increased satiety Decreased free fatty acid concentrations Decreased body weight However, the therapeutic use of native GLP-1 is limited by its very short half-life and rapid degradation

While the medications themselves remain undetectable in routine laboratory work, their therapeutic effectsincluding improved hemoglobin A1c, fasting glucose, and lipid profilesare clearly measurable

Beneficial Consequences of GLP-1RA Effects on Gastric Emptying Reduction in Postmeal Glycemic Excursions Elevation of postprandial glycemia (PPG) is characteristically the initial defect in glucose intolerance (1) and is a challenging aspect of the management of T2D (2)

Alcohol is a poor choice on injection day for several reasons, not least because it dehydrates you and can compound nausea