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For patients with an A1C less than 7.5%, monotherapy is recommended
We all moan over the potential successes that were missed, but in reality they were among many many more promising drugs that ended up being failures

Richards and colleagues 33 generated GLP-1R-Cre mice crossed with fluorescent reporter strains for identification and characterization of live cells expressing GLP-1R

Key Takeaway: Digestive side effects like diarrhea and constipation are common because GLP-1 medications slow down gastric emptying, which is the rate at which food moves through your digestive tract

doi:10.1056/NEJMoa1307684 100
