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Overall, theoretically, differences in the pharmacokinetic profiles of different GLP-1RAs may have important implications for their efficacy in BAD and perhaps help explain why liraglutide could be superior in reducing symptoms of BAD as compared with the more potent and longer-acting semaglutide

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Notably, lithium, the mood-stabiliser and frontline treatment for bipolar disorder, increases CaMKK2 activity by blocking GSK3-mediated phosphorylation of the S3-node [33]

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