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50 A recent meta-analysis including thirteen RCTs has shown that semaglutide and tirzepatide treatment significantly increases GI side effects such as nausea, vomiting, diarrhea, and constipation in obese individuals without diabetes compared to control groups

A natureza dos estudos frequentemente no randomizados ou com amostras pequenas demanda que mais ensaios clnicos sejam conduzidos para confirmar os benefcios e estabelecer protocolos teraputicos seguros

10.1016/j.metabol.2016.03.009 Metabolism 25 FontanellaR.GhoshP.PesapaneA.TaktazF.PuocciA.FranzeseM.et al (2024)

However, as with any weight loss treatment, its effectiveness for long-term management depends on several factors, including the individuals response to the medication and their ability to adopt and stick to a healthy lifestyle that includes proper nutrition and regular exercise

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