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In 2023, Fractyl Heath announced mice given semaglutide and treated with its gene therapy Rejuva, administered directly to the pancreas, had maintained a 22% weight loss for 28 weeks after stopping the drug and performed better than those given only semaglutide

This early effect occurs because semaglutide immediately begins signaling satiety pathways in the hypothalamus and brainstem

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PlexusDx providers work with patients to monitor symptom patterns and adjust dosing strategies based on individual tolerance, which is why personalized genetic testing can help identify which GLP-1 pathway variant you carry