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In the SURMOUNT-1 trial, tirzepatide produced dose-dependent weight reductions, with average losses approaching or exceeding ~20% at higher doses in adults with obesity who did not have diabetes, numbers that markedly exceed historical pharmacotherapy benchmarks

Clinical trial data indicate that gastrointestinal side effects occur in a substantial proportion of patients

Research overview Research bundle combining three compounds studied across complementary metabolic pathways

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Drug-based and surgical approaches should be considered solely as adjunctive measures supplementing this fundamental approach ( When lifestyle interventions prove insufficient, pharmacotherapy and metabolic/bariatric surgery (MBS) merit consideration