mazdutide vs semaglutide (IBI362): The Next-Generation Dual GLP-1/Glucagon Agonist for Obesity and Metabolic Health Updates in Medicine | Mazdutide
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It was a 2X return on ad spend (ROAS) right out of the gate
Dysesthesia signal (Phase 3) TRIUMPH-4 topline results, released December 11, 2025, reported dysesthesia in about 20.9% of participants at the highest dose

To address these issues, two orally available GLP-1 RAs are currently in clinical trials
Novo Nordisks share price is down 54% from its peak in June 2024

Such understanding could help in addressing the barriers to continued use of these medications
