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Diabetes 60, 218226
Consumption of drugs or alcohol can alter dopamine signaling in mesolimbic reward pathways, which helps reinforce substance-seeking behavior
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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
Inhibition of the cAMP-degrading enzyme phosphodiesterase 4 (PDE4) enhances and sustains these cAMP responses, and disruption of G s or cAMP signalling in AP Glp1r neurons abolishes semaglutide-induced weight loss and downstream brain-wide activation
