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However, because they slow gut motility, they may increase susceptibility in some individualsparticularly those with existing risk factors such as IBS, constipation, or prior gastrointestinal infections

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The relative expression levels of target genes were calculated using the 2 Ct method with glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as the internal reference gene

These include the use of step edits to discourage doctors from prescribing the more expensive drugs first

Therefore, there is no clinically relevant effect of renal impairment on TZT pharmacokinetics, and dose adjustment is not required for patients with renal impairment