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At pre-operation (RYGB surgery or EX-4 injection), at weeks 1, 2, 4, and 8, related indexes were monitored

There was no apparent effect of renal impairment, hepatic impairment or upper GI disease on the PK and tolerability of orally administered semaglutide, suggesting that dose adjustment is not necessary in these special populations [11, 31,32,33]

Beta-hydroxybutyrate levels, the most direct biomarker of glucagon-driven fat oxidation, increased meaningfully only at doses of 4mg and above

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