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Severe or bloody diarrhea requires immediate medical attention, as this is not a typical side effect of semaglutide and may indicate infection, inflammatory conditions, or other serious causes

The most common side effects of semaglutide are gastrointestinal, including abdominal discomfort and nausea

In our future work, we will examine the comparative effectiveness of alternative treatment options for obesity in patients who discontinue semaglutide or tirzepatide, to help patients and their clinicians make informed decisions. Cleveland Clinic is a nonprofit multispecialty academic medical center that integrates clinical and hospital care with research and education