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Description
Activation of POMC neurons promotes satiety, while inhibition of NPY neurons reduces hunger signaling

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2018;10(467):eaar7047
In that same study, 29% of people taking metformin daily lost greater than or equal to 5% or more of their initial body weight by the end of the first year, compared with 13% of people in the placebo group

Shimizu, N., Oomura, Y., Novin, D., Grijalva, C
