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The same framework that predicts AD efficacy also predicts GI tolerability: the calcium signaling network operates in both brain and gut, with the same proteins producing opposite clinical consequences in different tissues

Dyslipidemia, hyperglycemia, along with other metabolic disorders, results in IR and/or islet cell dysfunction via some shared pathways, such as inflammation, endoplasmic reticulum stress (ERS), oxidative stress, and ectopic lipid deposition

Evidence-based guidance for clinicians.

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