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Pasireotide drastically inhibited GLP-1 secretion induced by Gs-coupled receptor stimulation through SSTR5-Gi-dependent inhibition of cAMP levels, suggesting that the main pathway was completely blocked

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When GLP-1 receptor agonists (GLP-1RAs) were first approved over a decade ago, their primary indication was simple: help people with Type 2 diabetes manage their blood sugar

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Learn how GLP-1-based therapies like exenatide and liraglutide effectively reduce HbA1c, preserve beta cell function, and promote weight loss in type 2 diabetes.

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