how do glp 1 drugs help you lose weight Anti-obesity are closing the gap between dieting and bariatric surgery | Diet and Nutrition | Prevention Part 1 of a 3-Part

A JAMA Network Open retrospective cohort study of 125,474 adults with overweight or obesity: Patients with T2DM: 46.5% discontinued by year one 64.1% discontinued by year two Patients without T2DM: 64.8% discontinued by year one 84.4% discontinued by year two Nearly 85% of patients without diabetes stopped taking GLP-1s within two years

and awake tracheal extubation." 2.5 Comparison with Other Guidelines: 2.5.1 ASA Guidelines: A multisociety consensus for the perioperative management of patients taking GLP1 RAs was developed by representatives from: The American Society of Anesthesiologists The American Gastroenterological Association The American Society for Metabolic and Bariatric Surgery The International Society of Perioperative Care of Patients with Obesity The Society of American Gastrointestinal and Endoscopic Surgeons Recommendation 1 [2] : Consider variables that increase the risk of delayed gastric emptying and aspiration with the periprocedural use of GLP-1RA: - The escalation phase of the medication- Higher doses- Weekly dosing- The presence of gastrointestinal symptoms (nausea, vomiting, abdominal pain, dyspepsia, and constipation) suggestive of delayed gastric emptying- Other medical conditions that may delay gastric emptying

The drugs help with diabetes and weight loss, but they may also treat other conditions

4 GLP-1 RAs have been documented to stimulate brown fat metabolism, delay gastric emptying, and dampen satiety centers activity in the hypothalamus, advocating its potential use in the treatment of obesity and diabetes

59 REVIEW OF THE GUIDELINES According to the ADA 2022, 7 for patients with type 2 diabetes who also have established or a high risk of atherosclerotic cardiovascular disease, established kidney disease, or heart failure, an SGLT-2 inhibitor or GLP-1 receptor agonist with demonstrated cardiovascular benefit with or without metformin is recommended