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The expected pharmacy availability follows Health Canada's 180-day review timeline for generic drug applications

Cardiovascular outcome trials (including LEADER, SUSTAIN-6, REWIND, and SELECT) have demonstrated that certain GLP-1 receptor agonists reduce major adverse cardiovascular events in patients with established cardiovascular disease or multiple risk factors

The secondary renal outcome was a composite of the following components: new-onset persistent macroalbuminuria, persistent doubling of the serum creatinine level, ESRD, or death due to renal disease

Although periconceptional exposure to GLP-1 receptor agonists has not shown an increased risk of malformations, data on complications such as fetal growth restriction or embryonic death are lacking [188]

Restoration of euthyroidism is associated with improvements in fertility outcomes in these patients