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Impacto de los factores intrnsecos en la exposicin de semaglutida Edad: La edad no tuvo efecto sobre la farmacocintica de semaglutida, segn los resultados de los estudios de fase 3a realizados, que incluyeron a pacientes de 20-86 aos de edad

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Central nervous system (CNS): Chronic peripheral 54,66 and central 54 GIPR agonism decreases body weight by reduction in food intake, suggesting a CNS-mediated mechanism

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Bruno CD, Harmatz JS, Duan SX, Zhang Q, Chow CR, Greenblatt DJ