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Description
The antibody Fab7F38 appears to function by providing enhanced soluble surface area for crystal lattice packing, and indeed Fab7F38-bound GLP-1R can also assume an active conformation as shown by EM studies (see below), suggesting that Fab7F38 does not interfere with the conformational flexibility of the ECD during crystallization
This can also improve adherence
References 1.Malhotra A, Grunstein RR, Fietze I, Weaver TE, Redline S, Azarbarzin A (2024) Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity
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