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The FDA's adverse event reporting system depends on voluntary paperwork

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Nonetheless, although many experimental and clinical findings indicate that DPP-4 plays a role in the pathogenesis of autoimmune diseases, DPP-4 inhibition has controversial effects in autoimmune or inflammatory diseases, which might be related to the ubiquitous tissue distribution and tissue-specific regulation of DPP-4/CD26, as well as to the numerous functions and effects of DPP-4/CD26 [46]

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