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Its primary physiological functions include promoting glucose-dependent insulin secretion, enhancing hepatic glycogen synthesis, and increasing the buffering capacity of adipose tissue for lipids

The purpose of this review is to compare the clinical trial and real-world effectiveness data of glucagon-like peptide-1 receptor agonists versus sodiumglucose cotransporter 2 inhibitors related to A1c reduction, weight loss, cost-effectiveness, cardiovascular outcomes, and safety in patients with T2DM

A 2026 analysis published in the Annals of Pharmacotherapy (PMID 41480958) examined 25 OTC "GLP-1" transdermal products and found: Zero listed semaglutide, tirzepatide, or any FDA-approved GLP-1 agonist as an active ingredient

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