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Clinical trials including the SUSTAIN series (semaglutide) and SURPASS trials (tirzepatide) document net cardiovascular benefit in participants with or at risk for type 2 diabetes

Several molecules are currently available on the market, with partially different mechanisms of action, indications, dosages, and routes of administration (Table 1)

Shashank Sinha

The SGLT2i class showed significant relative risk reduction for the prevention of the composite kidney outcomes (35%) and for hospitalization for HF (32%) compared with placebo and superior to GLP-1RA

It is hard to predict who will be able to tolerate them and who wont, she said, although people who already struggle with gastrointestinal health issues may find these medications make them worse. Garcia-Webb added that clinically, she does find that people often have fewer side effects on Mounjaro than on Wegovy