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Dose adjustment considerations: If gastrointestinal symptoms are severe or persistent despite these measures, contact your prescribing clinician to discuss: Slowing the dose escalation schedule Temporarily reducing the dose Taking a brief treatment pause (though this may affect weight loss progress) Switching to an alternative weight management medication if symptoms are intolerable The STEP trials demonstrated that slower dose titration can reduce the incidence and severity of gastrointestinal adverse effects

Retatrutide Dosage Guide For Weight Loss: What We Know So Far Last Updated: 29 April 2026 Retatrutide is one of the most anticipated new medications in the world of weight management

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Most notice appetite changes in 1-3 weeks and weight loss within the first month

There is no specific antidote for semaglutide overdose, and effects may persist for several days due to the medication's extended half-life