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Risk of Retained Gastric Contents in Patients Using GLP-1RAs or Tirzepatide Presenting for Endoscopy or General Anesthesia Retrospective studies suggest that individuals on GLP-1-based therapy (exenatide, liraglutide, dulaglutide, semaglutide, or tirzepatide) appear to be at an increased risk of having retained gastric contents [Supplementary Table S3 (21)

These animal models have also explored whether G protein-coupled taste receptor expression is altered in obesity models, particularly in leptin-deficient ob/ob mice and diet-induced obesity models (122)

This approach reflects the success seen with SGLT2 inhibitors, which have demonstrated significant cardioprotective and anti-inflammatory effects in conditions such as SLE, leading to their integration into clinical practice for autoimmune diseases (83)

This does not include the cost of medication

If symptoms become persistent or disruptive, we reassess promptly to maintain both safety and comfort